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Regensburg 2004 – scientific programme

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SYLS: Life Sciences on the Nanometer Scale - Physics Meets Biology

SYLS 3: Symposium "Life Sciences on the Nanometer Scale - Physics Meets Biology"

SYLS 3.40: Poster

Wednesday, March 10, 2004, 16:00–18:30, B

Single cell manipulation in microfluidic networks by optical tweezers — •Kai Leffhalm1, Andy Sischka1, Wibke Hellmich1, Thanh Tu Duong1, Annika Grabbe2, Jürgen Wienands2, Katja Tönsing1, Robert Ros1, Alexandra Ros1, and Dario Anselmetti11Experimental Biophysics, Physics Department, Bielefeld University, Germany — 2Biochemistry, Department of Chemistry, Bielefeld University, Germany

Experiments with single cells gain importance as a tool to better understand the behaviour of living cells in vivo. Microfluidic networks provide dimensions small enough to navigate a single cell with optical tweezers to different areas of the artificial network where the flow properties can be controlled by electrophoresis and electroosmosis.

The expression of special proteins in a cell can be stimulated or suppressed by changing the velocity of the flow or the concentration of substances, e.g. cytokines or (cytostatic) drugs, in the culture medium.

We will present our experimental setup and our first test experiments for future applications in monitoring the expression level of individuell cells and microproteomics.

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