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AKB: Biologische Physik

AKB 40: Poster Session II

AKB 40.8: Poster

Mittwoch, 29. März 2006, 16:30–19:30, P3

Vasculature remodeling in tumor-induced angiogenesis – a stochastic model — •Raja Paul¹, Katalin Bartha², and Heiko Rieger³ — ¹BIOMS, IWR, Ruprecht-Karls-University Heidelberg, D-69120 Heidelberg, Germany — ²Department of Medical Biochemistry, Semmelweis University, Budapest, Hungary — ³Theoretische Physik, Universität des Saarlandes, D-66041 Saarbrücken

Based upon a recently introduced model[1] for vascular network remodeling via vessel cooption, regression and growth in tumors[2] we study a dynamically evolving two-dimensional biconnected network incorporating the effect of probabilistic neo-vascularization and vessel collapse. The morphology of a regular vasculature is drastically changed in the presence of an expanding tumor. Independent vessel collapse results in a percolation transition of the network, flow correlated collapse stabilizes the network in the tumor center at a non-vanishing microvascular density (MVD). MVD, blood flow and shear force has been computed for a wide range of parameters and found to be in good qualitative agreement with experimental data[3] for human melanoma.

[1] K. Bartha and H. Rieger, q-bio.TO/0506039.

[2] D. Hanahan and J. Folkman, Cell, 86, 353 (1996).

[3] B. Döme, S. Paku, B. Somlai and J. Tímár, J. Path., 197, 355 (2002).