Bereiche | Tage | Auswahl | Suche | Downloads | Hilfe
BP: Fachverband Biologische Physik
BP 28: Biomedical Applications
BP 28.4: Vortrag
Freitag, 30. März 2007, 11:45–12:00, H44
Ellipsometric studies on protein adsorption kinetics — •Christoph Gilow1, Hubert Mantz1, Anthony Quinn1, Karin Jacobs1, Markus Bellion2, and Ludger Santen2 — 1Saarland University, Experimental Physics, D-66041 Saarbrücken, Germany — 2Saarland University, Theoretical Physics, D-66041 Saarbrücken, Germany
Adsorption processes of proteins play an important role in many biomedical systems. Examples are the protein films on teeth or tissue compatibility.
From a physical point of view these processes raise a number of challenging questions, e.g., which substrate properties (chemical composition, roughness,…) have an impact on protein adsorption.
We investigated the adsorption kinetics of several salivary proteins in a liquid environment on tailored substrates by means of ellipsometry and found a new type of adsorption kinetics. A comparison to extensive Monte Carlo simulations strongly suggests that long-range contributions to the surface potential lead to conformational changes of the protein on the surface which are responsible for the observed unusual kinetics of the amylase.