Berlin 2008 – scientific programme

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BP: Fachverband Biologische Physik

BP 26: Posters II

BP 26.45: Poster

Thursday, February 28, 2008, 17:00–19:30, Poster A

Simulation of protein kinase C alpha (PKCα) membrane translocation processes — •Martin Peglow and Heiko Rieger — Theoretische Physik, Universität des Saarlandes, PF 151150, D-66041 Saarbrücken

PKCα is a versatile key for decoding the cellular calcium toolkit. During their measurements of PKCα membrane translocations, which are activated through intracellular Ca²⁺ release, Reither and Lipp [1] found two populations of so called Local Translocation Events (LTEs). One population whose life times correspond to the duration of the underlaying Ca²⁺-signals and a second population the so called long lasting LTEs ( T > 4s ). The source or appearance of the long lasting LTEs can’t be explained for sure. Theoretical assumptions for possible mechanisms shall be verified by our simulations. An efficient Monte Carlo algorithm for simulations of reaction-diffusion kinetics in single cells, the ”Next Subvolume Method” [2], is presented here.

[1] Dr. Gregor Reither, EMBL Heidelberg and Prof. Peter Lipp, Institut für Molekulare Zellbiologie Universität des Saarlandes, JCB, 174, 521, (2006)
[2] J. Elf, A. Doncic, M. Ehrenberg, Proceeding of SPIE, 5110, (2003)