Berlin 2012 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 27: Posters: Cytoskeletal Filaments

BP 27.5: Poster

Donnerstag, 29. März 2012, 17:30–19:30, Poster A

Measurements of F-actin tube conformation — Evelin Jaschinski, Inka Lauter, Bernd Hoffmann, and •Rudolf Merkel — Forschungszentrum Jülich GmbH, Wilhelm-Johnen-Straße, 52428 Jülich

Actin is a major component of the cytoskeleton of almost all eukaryotic cells. In thermal equilibrium in vitro polymerized actin filaments (F-actin) are fluctuating. These fluctuations are restricted by surrounding filaments which form a tube like volume. The propability distribution of the tube dimension has been measured by means of confocal fluorescence microscopy in our group [1, 2]. Based on these results we are analyzing the F-actin tube conformation under specific external conditions like enforced alignment exerted by shear force as well as counterions.

[1] J.Glaser, D. Chakraborty, K. Kroy & I. Lauter, M. Degawa, N. Kirchgeßner, B. Hoffmann, R. Merkel, M. Giesen, Phys. Rev. Lett. 105, 037801 (2010)

[2] M. Romanowska, H. Hinsch, N. Kirchgeßner, M.Giesen, M. Degawa, B. Hoffmann, E. Frey, R. Merkel, EPL 86, 26003 (2009)