Hannover 2013 – wissenschaftliches Programm
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Q: Fachverband Quantenoptik und Photonik
Q 43: Poster II
Q 43.22: Poster
Mittwoch, 20. März 2013, 16:00–18:30, Empore Lichthof
Cancer cell therapy by upcoversion UV emission from Pr:YAG nanoparticles — Kangwei Xia1, •Gengxu Chen1,2, Andrea Zappe1, Rolf Reuter1, Rainer Stöhr1, Tugrul Inal1, Jan Meijer3, Roman Kolesov1, and Jörg Wrachtrup1 — 13. Physikalisches Institut, Universität Stuttgart, Pfaffenwaldring 57, Stuttgart, D-70569, Germany — 2State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai, 200062, China — 3RUBION, Ruhr-Universität Bochum, Bochum, D-44780, Germany
Recently, rare-earth ions doped inorganic crystals have been introduced into cellular microscopic studies as new types of biomarkers due to optical upconversion process [1]. Furthermore, optical upconversion process in rare-earth doped materials can produce ultraviolet (UV) emission with visible or even infrared excitation. If such nanoparticles are located inside living cells, the cells will be killed by the UV emission with an appropriate excitation on the nanoparticles [2]. Here, we demonstrated the apoptosis of the HeLa cells incubated in a buffer containing Pr:YAG nanoparticles, which is on account of the photochemical effect caused by upconversion UV emission of Pr:YAG nanoparticles [2,3]. Our study might pave a way to novel methods of laser-assisted cancer treatment.
Reference [1] F. Wang and X. Liu, Chem. Soc. Rev. 38, 976-989 (2009) [2] R. Kolesov, K. Xia, R. Reuter, R. Stöhr, A. Zappe, J.Meijer, P.R. Hemmer, and J.Wrachtrup, Nat. Commun. 3:1029 doi: 10.1038/ncomms2034 (2012). [3] R. Kolesov, R. Reuter, K. Xia, R. Stöhr, A. Zappe, and J. Wrachtrup, Phys. Rev. B 84, 153413 (2011)