Dresden 2017 – wissenschaftliches Programm

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AKBP: Arbeitskreis Beschleunigerphysik

AKBP 6: Poster Session

AKBP 6.2: Poster

Mittwoch, 22. März 2017, 18:30–20:00, P4

The applicability of dielectric laser accelerators as an ultrashort microbeam radiation source for single-cell experiments — •Anna Mittelbach¹, Joshua McNeur¹, Martin Kozák¹, Johannes Illmer¹, Anna A. Friedl², Luitpold Distel³, and Peter Hommelhoff¹ — ¹Department Physik, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen — ²Department für Strahlentherapie, Ludwig-Maximilians-Universität München (LMU), München — ³Department für Strahlentherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen

Dielectric laser accelerators enable a variety of new applications [1]. Due to their miniaturized scale and potential as a pen-sized MeV electron source, one such application is as an intraoperative oncological irradiation device. Here we discuss the design of an experiment meant to test the feasibility of this application. A laser-triggered 50 keV Schottky-emitter is used as the electron source, due to its similarity to the anticipated DLA beam. We aim to monitor double strand breaks induced in the DNA of these cells after the irradiation process via γ-H2AX assay [2]. From these results, we investigate the influence of ultrashort pulsed microbeams on biological targets. The current status of the experiment will be reported.

[1] R. J. England et al., Dielectric laser accelerators. Rev. Mod. Phys. 86, 1337-1389 (2014)

[2] E.P. Rogakou et al., DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139. J. Biol. Chem. 273, 5858 (1998)