Dresden 2017 – scientific programme
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AKBP: Arbeitskreis Beschleunigerphysik
AKBP 6: Poster Session
AKBP 6.2: Poster
Wednesday, March 22, 2017, 18:30–20:00, P4
The applicability of dielectric laser accelerators as an ultrashort microbeam radiation source for single-cell experiments — •Anna Mittelbach1, Joshua McNeur1, Martin Kozák1, Johannes Illmer1, Anna A. Friedl2, Luitpold Distel3, and Peter Hommelhoff1 — 1Department Physik, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen — 2Department für Strahlentherapie, Ludwig-Maximilians-Universität München (LMU), München — 3Department für Strahlentherapie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen
Dielectric laser accelerators enable a variety of new applications [1]. Due to their miniaturized scale and potential as a pen-sized MeV electron source, one such application is as an intraoperative oncological irradiation device. Here we discuss the design of an experiment meant to test the feasibility of this application. A laser-triggered 50 keV Schottky-emitter is used as the electron source, due to its similarity to the anticipated DLA beam. We aim to monitor double strand breaks induced in the DNA of these cells after the irradiation process via γ-H2AX assay [2]. From these results, we investigate the influence of ultrashort pulsed microbeams on biological targets. The current status of the experiment will be reported.
[1] R. J. England et al., Dielectric laser accelerators. Rev. Mod. Phys. 86, 1337-1389 (2014)
[2] E.P. Rogakou et al., DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139. J. Biol. Chem. 273, 5858 (1998)