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BP: Fachverband Biologische Physik

BP 20: Statistical Physics of Biological Systems DY (joint session DY/BP)

BP 20.7: Vortrag

Mittwoch, 14. März 2018, 11:45–12:00, BH-N 333

Nonlinear Dynamics of Calcium Cycling in Cardiomyocytes — •Filippo G. Cosi¹, Stefan Luther^{1, 2, 3, 4, 5}, and Ulrich Parlitz^{1, 2, 4} — ¹Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — ²Georg-August-Universität Göttingen, Institute for Nonlinear Dynamics, Göttingen, Germany — ³University Medical Center Göttingen, Institute of Pharmacology and Toxicology, Göttingen, Germany — ⁴DZHK (German Center for Cardiovascular Research), partnersite Göttingen, Germany — ⁵Department of Physics and Department of Bioengineering, Northeastern University, Boston, USA

Delayed or early after depolarisations and Calcium alternans inside single cardiomyocytes are known to alterate the sane dynamics of the muscle cell leading to heart defects and even failure on a greater scale.

Defects in the subcellular components, like Rynodine Receptors (RyR) or Sodium-Calcium Exchangers (NCX) are believed to be the cause of these depolarisations and alternans. In our project, we therefore investigate how these defects are influencing the Calcium and membrane potential dynamics on a cellular scale. A mathematical model including both, the stochastic nature of the cellular components and the whole cell Calcium dynamics, is developed.

Calcium waves, showing a sequential and spontaneous activation of the cell, are presented as results of the model together with the main structure of the algorithm. Diffusive Calcium waves are assumed to be one of the symptoms of diseased ventricular cardiomyocytes causing Calcium alternans and delayed after depolarisations.