Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 20: Statistical Physics of Biological Systems DY (joint session DY/BP)
BP 20.7: Vortrag
Mittwoch, 14. März 2018, 11:45–12:00, BH-N 333
Nonlinear Dynamics of Calcium Cycling in Cardiomyocytes — •Filippo G. Cosi1, Stefan Luther1, 2, 3, 4, 5, and Ulrich Parlitz1, 2, 4 — 1Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 2Georg-August-Universität Göttingen, Institute for Nonlinear Dynamics, Göttingen, Germany — 3University Medical Center Göttingen, Institute of Pharmacology and Toxicology, Göttingen, Germany — 4DZHK (German Center for Cardiovascular Research), partnersite Göttingen, Germany — 5Department of Physics and Department of Bioengineering, Northeastern University, Boston, USA
Delayed or early after depolarisations and Calcium alternans inside single cardiomyocytes are known to alterate the sane dynamics of the muscle cell leading to heart defects and even failure on a greater scale.
Defects in the subcellular components, like Rynodine Receptors (RyR) or Sodium-Calcium Exchangers (NCX) are believed to be the cause of these depolarisations and alternans. In our project, we therefore investigate how these defects are influencing the Calcium and membrane potential dynamics on a cellular scale. A mathematical model including both, the stochastic nature of the cellular components and the whole cell Calcium dynamics, is developed.
Calcium waves, showing a sequential and spontaneous activation of the cell, are presented as results of the model together with the main structure of the algorithm. Diffusive Calcium waves are assumed to be one of the symptoms of diseased ventricular cardiomyocytes causing Calcium alternans and delayed after depolarisations.