Erlangen 2018 – wissenschaftliches Programm
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MS: Fachverband Massenspektrometrie
MS 6: Accelerator Mass Spectrometry 2
MS 6.2: Vortrag
Donnerstag, 8. März 2018, 11:00–11:15, R 1.020
Design of a new Gas Interface for biomedical 14C analyses — •Daniele De Maria1, Simon Fahrni2, Lukas Wacker1, and Hans-Arno Synal1 — 1Laboratory of Ion Beam Physics, ETH Zurich, Switzerland — 2Ionplus AG, Dietikon, Switzerland
Radiocarbon analyses by accelerator mass spectrometry (AMS) have a great potential for biomedical applications, in particular in pharmacokinetic studies using 14C as a microtracer. Thus, the AMS approach for this research field was investigated in a validation study conducted in collaboration with Novartis (Basel, Switzerland) to evaluate the performance of the MICADAS. Since these studies require the measurement of a large number of samples in a short period of time, a key problem of AMS technology is its low sample throughput. Therefore, our aim is to develop a new gas handling system to achieve a faster measurement process for applications where low precision but higher throughput is required. The design of the new interface will be presented, focusing in particular on the strategies to overcome the time consuming cleaning procedure required after each sample to avoid cross-contamination.