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BP: Fachverband Biologische Physik

BP 12: Poster II

BP 12.15: Poster

Dienstag, 2. April 2019, 14:00–16:00, Poster B2

Nanomorphology of living sinus nodal cells — •Max Ulbrich¹, Mirco Wendt¹, Julia J. Jung², Christian Völkner¹, Regina Lange¹, Heiko Lemke², Christian Rimmbach², Robert David², Ingo Barke¹, and Sylvia Speller¹ — ¹Institute of Physics, University of Rostock, 18051 Rostock — ²Reference and Translation Center for Cardiac Stem Cell Therapy, University Medical Center Rostock, 18057 Rostock

Cardiomyocytes exhibit electro-mechanical activity and may therefore be envisioned as sensor or actuator cells. Sinus nodal cells form the pacemaker of the heart and exhibit autonomous activity while working myocardial cells follow their pace. In our studies, we use scanning ion conductance microscopy (SICM) [1] to observe the live-cell morphology and surface dynamics of individual sinus nodal cardiomyocytes derived by forward programming of pluripotent stem cells [2]. Here, we focus on the question whether the sinus nodal cell subtype exhibits characteristic features on its surface which can help to conclude on their origin as well as functionality.

[1] C-C Chen et al., Annu. Rev. Anal. Chem. 5, 207 (2012)

[2] J.J. Jung et al., Stem Cell Rep. 2, 592 (2014)