Dresden 2020 – scientific programme
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BP: Fachverband Biologische Physik
BP 19: Poster VII
BP 19.9: Poster
Tuesday, March 17, 2020, 14:00–16:00, P2/3OG
Uncertainty quantification for electromagnetic models of biological cells based on dielectric spectroscopy data — •Julius Zimmermann1, Fukun Shi2,3, Jürgen Kolb2,3, and Ursula van Rienen1,4 — 1Institut für allgemeine Elektrotechnik, Universität Rostock, 18051 Rostock — 2Institut für Physik, Universität Rostock, 18059 Rostock — 3Leibniz-Institut für Plasmaforschung und Technologie (INP), 17489 Greifswald — 4Department Life, Light & Matter, Universität Rostock, 18051 Rostock
Developing reliable models to understand the interaction between electromagnetic fields and biological cells is a challenging task due to a lack of precise data. We present an approach to estimate the induced transmembrane potential. The approach is based on the electroquasistatic formulation of Maxwell's equations and requires knowledge of the conductivity and relative permittivity of the different constituents of the system under investigation (that is cell membrane, cytoplasm and extracellular medium). We estimate the required parameters from dielectric spectroscopy data. Based on the estimate's uncertainty, the uncertainty of the model output is estimated in a mathematically rigorous fashion.
Acknowledgement: This research was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) within the Collaborative Research Centre 1270 ELAINE.