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BP: Fachverband Biologische Physik

BP 19: Poster VII

BP 19.9: Poster

Dienstag, 17. März 2020, 14:00–16:00, P2/3OG

Uncertainty quantification for electromagnetic models of biological cells based on dielectric spectroscopy data — •Julius Zimmermann¹, Fukun Shi^2,3, Jürgen Kolb^2,3, and Ursula van Rienen^1,4 — ¹Institut für allgemeine Elektrotechnik, Universität Rostock, 18051 Rostock — ²Institut für Physik, Universität Rostock, 18059 Rostock — ³Leibniz-Institut für Plasmaforschung und Technologie (INP), 17489 Greifswald — ⁴Department Life, Light & Matter, Universität Rostock, 18051 Rostock

Developing reliable models to understand the interaction between electromagnetic fields and biological cells is a challenging task due to a lack of precise data. We present an approach to estimate the induced transmembrane potential. The approach is based on the electroquasistatic formulation of Maxwell's equations and requires knowledge of the conductivity and relative permittivity of the different constituents of the system under investigation (that is cell membrane, cytoplasm and extracellular medium). We estimate the required parameters from dielectric spectroscopy data. Based on the estimate's uncertainty, the uncertainty of the model output is estimated in a mathematically rigorous fashion.

Acknowledgement: This research was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) within the Collaborative Research Centre 1270 ELAINE.