Berlin 2024 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 20: Poster IIIa

BP 20.28: Poster

Mittwoch, 20. März 2024, 11:00–14:30, Poster B

A Study on Tradeoffs Induced Landscapes Model — •Muna Turki¹, Suman Das², Muhittin Mungan³, Rotem Gross⁴, and Joachim Krug⁵ — ¹Institute of Biological Physics - University of Cologne — ²Institute of Ecology and Evolution - University of Bern — ³Institute of Biological Physics - University of Cologne — ⁴Institute of Biological Physics - University of Cologne — ⁵Institute of Biological Physics - University of Cologne

Effects mutations have on the fitness of a genotype are environment dependent. The endangering pressure of antibiotics directs bacterial cultures towards the selection of resistant mutants. These resistant mutants are equipped with mutations that increase the fitness of bacteria in the presence of antibiotics allowing for adaptation, however they come with a cost in the form of decreasing fitness in absence of antibiotics as the resistant mechanisms the mutant bacteria develop tend to be energy-costly, which is a tradeoff the mutant has to endure.

Tradeoff Induced Landscape (TIL) is a mathematical model that was motivated by antibiotic dose-response curves of Ciprofloxacin resistance in Escherichia coli strains which model evolution in a changing environment through adaptation-cost tradeoffs. The model assumes a non-epistatic accumulative effect of mutations on the fitness parameters, generating fitness landscapes with exceptionally smooth topology and high accessibility.

Recent experimental data on evolution of Escherichia coli in the context of β-lactam resistance are available through which the model could be tested and modified.

Keywords: Resistance Evolution in Bacteria; Tradeoffs; Fitness Landscape; β−lactam Resistance; Diminishing Returns Epistasis