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CPP: Fachverband Chemische Physik und Polymerphysik

CPP 3: Crystallization, Nucleation and Self-Assembly I

CPP 3.9: Talk

Monday, March 18, 2024, 12:00–12:15, H 0110

Electric-field effects on protein phase behavior — Debes Ray¹, Mahnoush Madani², Jan K. G. Dhont¹, •Florian Platten^1,2, and Kyongok Kang¹ — ¹FZ Jülich, IBI-4, Jülich, Germany — ²HHU Düsseldorf, Faculty of Mathematics and Natural Sciences, Düsseldorf, Germany

We experimentally study the state diagram of protein solutions in the presence of a weak external alternating-current electric field. The collective behavior of the protein solutions and their response to the electric field are followed in-situ by polarized optical microscopy. The crystallization boundary and the metastable liquid-liquid coexistence curve are affected by the electric field, such that the crystallization gap is widened. Both nucleation and growth of protein crystals can be modulated by the frequency and strength of the field.

Keywords: protein phase behavior; protein crystallization; LLPS